i just bought the PXC250 last friday... and the ANC is quite good... was working with jigsaws and drills over the weekend and i had the PXCs on throughout..
the sound quality was also decent... though the bass was a bit lacking, the clarity was there. sound was a bit warm as well. fitting wise, it did slip out a bit when i moved around but i guess coz my ears are quite big and the ear pads were a bit small. but it was comfortable when it stayed on. didn't feel like i had them on, in fact.
well worth the S$259 i paid... btw, sennheiser gave me a set of in ear phones (MX400) free as a promotional deal..